Stem-Cells to cure SCI – The Latest News

Few articles about latest discoveries and advancements in the stem-cell field.

They all refer to research and experiments on acute injured Lab Rats but some Human studies and even trials are planned.

UC San Diego has discovered a way to grow nerve fibers in rats with severe spinal cord injury. Researchers used stem cells to basically rewire the central nervous system, enabling the rats to regain some movement. The technique, reported in the journal Cell, causes connections from neurons to spread beyond the injury, restoring the ability of the brain and spine to communicate.

http://www.utsandiego.com/news/2012/sep/13/ucsd-finds-possible-path-treating-spinal-cord-inju/?sciquest

 

ROCKVILLE, Md., Sept. 13, 2012 /PRNewswire/ — Neuralstem, Inc. (NYSE MKT: CUR) announced that its neural stem cells were part of a study, “Long-Distance Growth and Connectivity of Neural Stem Cells After Severe Spinal Cord Injury: Cell-Intrinsic Mechanisms Overcome Spinal Inhibition,”   In the study, rats with surgically transected spinal cords, which rendered them permanently and completely paraplegic, were transplanted with Neuralstem’s spinal cord stem cells (NSI-566). The study reports that the animals recovered significant locomotor function, regaining movement in all lower extremity joints, and that the transplanted neural stem cells turned into neurons which grew a “remarkable” number of axons that extended for “very long distances” over 17 spinal segments, making connections both above and below the point of severance. These axons reached up to the cervical region (C4) and down to the lumbar region (L1). They also appeared to make reciprocal synaptic connectivity with the host rat spinal cord neurons in the gray matter for several segments below the injury.

http://investor.neuralstem.com/phoenix.zhtml?c=203908&p=irol-newsArticle&ID=1734926

http://www.sciencedirect.com/science/article/pii/S0092867412010239

http://www.cell.com/abstract/S0092-8674(12)01018-5

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