My testing of New medication – 4-AP-3-MeOH

  This my own observation and it’s not based on any medical & scientific
basis, methods or guidelines. I would ask anyone to take caution and consult
doctor before trying to repeat any of my ideas.

Conclusion: Potassium channel blocker – 4-AP-3-MeOH – New signal enhancer medication – will increase ability of damaged or less functional nerves to conduct signals and can help with exercise, in functional recovery program and during the rehab for Incomplete Spinal Cord Injuries.
green-light-walk
With medication 4-AP-3-MeOH (currently 2 x 0.5 mg daily) I am taking for the last 4 weeks,
I am actually improving my posture and my ability to walk in higher platform
walker with knee braces (time and distance).  Also, this medication is cause of increased
time and strength of pushing and frequency of good steps and time
of walking on treadmill with.suspended weight.

I have no side-effects so far and I am trying to keep “monitoring” and I will post any changes here.

Dosage is crucial. I got my capsules as 0.5 mg (as this compound is
10x stronger than  Ampyra) and I have started by one daily, increasing
to 2, 3 and 4 daily slowly and decreasing slowly back to 2 daily within 2 weeks period.
I didn’t notice any side effects except slightly buzzing in my head when I had 4 x 0.5 mg**
(**which is, anyway hard to confirm with my chronic tinnitus 🙂 .
During this period and all time taking 4-AP-3-MeOH I did not take an alcohol or any other drug except aspirin.

I have very significant firmness in my legs, in my core, my non working fingers flickering.
My spasms didn’t increased with 4-AP-3-MeOH as with Ampyra in May this year,
rather there is less spasms, but when spasms happens they are stronger.
Somehow, my overall energy increased. Ability to voluntary and functionally move limbs just slightly increased.

Now I am planing to stop taking this cat – “MeeeOH” as I call it, for
a week or 2 to cleanse little bit, get some wine and see how this period without drug
will reflect on me and I am planning to start to take another round after that and I
will try to increase my exercise level along with dosage, to maybe 5 x 0.5 mg in time of heavy workouts. I am pretty sure that gradually increasing dosage in time of heavy exercise program time and than gradually decreasing dosage for less activity period is safe to do.

According to all research and data comparison, only benefits, old incomplete SCI
patients would get from long (6 months at least) and extremely hard walking exercise program.
If accompanies this exercise program with medication that increase signal strength (as 4-AP-3-MeOH) and possibly even use a system as Parastep (Functional Electric Stimulation & suspended weight walk), chances for good outcome would be much higher.

comad-parastep

This compound drug is available from several places and I got 100
capsules for US $ 100 from UK compound pharmacy mod4all.com .
Shelf life is apparently much longer (18-24 months) than 4AP.

IN DEPTH

Since my SCI Injury (C-6 Incomplete) 12 years ago in waves of Virginia
Beach, I am trying to put together extremely complex and by medicine science
impossible-to-solve puzzle with picture of myself walking again.
After being ditched by Canadian Health care system that would rather promote dependability and assists business of wheelchair & various equipment & supplies, health care system that would  never prescribe more than 12 physio therapies through 1 year (1 per month) for “chronic” spinal cord injuries, I have found myself paying for my own physio-therapies overseas, in my native Bosnia & Herzegovina in Rehab center in Fojnica, where I had recovered within 3 months to be able to walk in parallel bars with knee braces only.
komadina-razboj
Unfortunately I was able to travel to that rehab only twice (by 3 months) within 2 years
after my injury. With every return to Canada and after longer periods
without quality & quantity exercises, I lost all achieved improvements.
I knew that any improvement with my condition will be very hard to
achieve but I had no Idea will be so easy to lose it.
Only way to get lasting effect will be to exercise long & hard enough to put your mind and body  over the threshold that will make yourself (body) going into mode of self recovery.
Only some very small percent of people figure out how to do it and did it.
As every incomplete injury is different there is no template, manual how to do it.
Each and every one of us, prisoners of our own broken body need to
find our own way, and everyone’s recovery and exercise program should
be custom and different.
However, some things works for All Incomplete Spinal Cord Injuries!
Program based on controlled and focused exercises, specially standing and walking (with
necessary help of others or help of needed devices) as often as possible over some longer period of time (at least 6 months) would bring certain improvement to any incomplete SCI person!
Some people recover more, some less  – depend of several factors.

SCIENCE BEHIND

With incomplete SCI you can often find that only one smaller part of
the spinal cord has been damaged, contused, bruised with only some
nerves physically cut and the most of nerves intact.
Due to immediate “short circuit” reaction  within spinal cord in moment or immediately after the
injury patient will go into “spinal shock” state, where the most neuro-signals below injury level are cut off. Even their intact nerves stop conducting proper signals.
In some cases person get lucky and after some time spinal shock effect
diminishes over the time and some of the functions get returned.
What is real mechanism of spinal shock and how its working is still great mystery.
Now, some of non-cut nerves that refuse to come back into conduction
signal mode are actually overstretched or contused / compressed
and their axons (center part of nerve) are intact but their own
insulation myelin sheet are jeopardized, so signal transfer has been interrupted.
That interruption could cause very weak, sporadic signal that for
effect has limited or weak ability of certain muscles to contract /
move or they can cause sporadic or more constant spasm’s.
Thanks to potassium channel blockers that acting as artificial nerve
insulators (Pyridine’s group (4-AP) ),
patient can get extra help in effort to re-establish neurological pathways.
Problem with potassium channel blockers is they can cause side effects.
Some side effects can be serious as epileptic seizures and due to
highly unique “configuration” of every injury, it is almost impossible
to establish universal dosage. That’s why each patient who is taking potassium
channel blockers need to go through careful ramping process to find
out what dosage will work for him / her.
There are several pyridine based blockers – first, the oldest one is
generic 4-AP drug know for few decades, made by compound pharmacies and
used by lot of people with more or less success.
There is also slow release version of the same drug approved about 5
years ago known as Ampyra in USA (Fampyra – Canadian version).
This drug is very expensive ($ 600 – $ 900 monthly dose) for non
insured people and it is approved for MS patients but never officially
approved for Spinal Cord injured patients exactly from the same reason of inability to
establish universal dosage.
Third generation of this drug is 4-AP-3-MeOH, 10 X stronger and with
less side effects than predecessors.
This drug came from Lab of Dr. Shi (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019253/ )
and it was tested on animals only – never being tested on humans.

BEFORE MY EXPERIENCE WITH 4-AP-3-MeOH AND SOME OTHER EXPLANATIONS

Yes, I feel as a Lab Rat…testing alone something that was tested on animals only.
Well,  I have already tried, by my Spinal Cord doctor prescribed, similar medcation
“Ampyra” in May of this year when I visit again Rehab center in Bosnia
and after few weeks I didn’t notice almost any serious side effects taking
2 x 10 mg recommended dose of this medication..
I was there in SCI Rehab Clinic for 45 days and once I had
finished my training session in rehab center in Bosnia I have stop taking
Ampyra. With Ampyra, major differences caused with this medication were
overall 200% greater stiffness of my legs and some stronger spasm’s.
In that Rehab time I have focused more on core and lower back
exercises and not on walking.

Let me explain something – about use of “walking” term here:
There are 2 type of “walking” I perform – walking with knee braces in
tall platform walker with belt behind me and there is also
suspended weight type of walking on treadmill with help of my feet positioning.
I have platform walker in my home and usually walk every morning 30
min or less after stretching exercises.
BXL-Steadymate-walker
This walk I call “Frankenstein” walk with knee braces that lock my
knees for standing and stiffing my legs bearing full body weight.
braces1
Second type is “more natural” , knee bending walk and I am able to do
it @ MacWheelers gym in Hamilton Ontario, thanks to the staff & students
of McMaster University /  Kinesiology / Volunteers.
Twice per week by 30 – 35 minutes I am walking with half of my weight
suspended over the treadmill and 2 students are helping me with moving
and positioning my feet.
johnny-walker3
With 4-AP-3-MeOH (2 x 0.5 mg daily) that i am taking for the last 4
weeks, I am actually improved and hope to keep improving by
lowering suspended weight (from 63 to 50 kilos just recently) and
increasing frequency of good steps.

Again, I will keep “monitoring” and I will post any changes here.
Your comments are welcomed!

Sincerely,
Zel Komadina
Miracle of Walk

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11 thoughts on “My testing of New medication – 4-AP-3-MeOH

  1. comad, i ordered 4-ap-2-meoh. i’m c 3/4 injured and been using walker for short distances. hope one capsule enough or me. got tight spasticity not limp as i suspect you have maybe? -jan fellowhawkeye

  2. Hi Zel – I have an incomplete spinal cord injury as well. I currently take 4AP but would like to try out the 4-aminopyridine-3-methanol you mentioned. Where do you get it? Do you still like it better than 4AP? Thank you!!

    Diana

  3. Are you still using this? How are you doing? I have had MS for 29 and would like to try this before I look for actual bee venom. I had a seizure from Ampyra and now only smoking weed and taking aspirin for pain and spasms.

    • I am very sorry, looks I’ve missed your comment and question.
      No, I am not using 4-AP-3-MeOH as I can not find good supply source.
      This medication is very good – much better than 4AP or Ampyra, but not available in pharmacies or compound pharms and only known source was mod4all.com but they had some problems with delivery as well.

  4. Here below you will find some excerpts from published scientific researches in animal models as medication has not been tested on humans officially (unless you consider my testing and use of this medication by some people around globe.)
    Good place to see people exchanging some ideas about potassium channel blockers is here on CareCure.org Forum:
    http://sci.rutgers.edu/forum/showthread.php?257188-Both-4-AP-and-stem-cell-treatment-target-demyelinated-axons-for-better-CNS-conduction
    * * *
    While 4-AP-3-MeOH clearly shows strong efficacy in restoring axonal conduction when compared to 4-AP in mechanically injured spinal cords, such comparison has not been conducted in chemically-injured axons prior to the current study (Jensen and Shi, 2003; Sun et al., 2010). The current investigation was the first to examine the effect of 4-AP-3-MeOH in restoring spinal cord CAP amplitude following the exposure of acrolein which is known to cause myelin damage (Yan et al., 2016). In addition, both 4-AP and 4-AP-3-MeOH were tested side-by-side in the same study for the first time. This study confirmed that 4-AP-3-MeOH works to restore conduction in axons with acrolein-mediated myelin damage and also displayed greater efficacy and wider therapeutic range than 4-AP. Furthermore, 4-AP-3-MeOH restores axonal conduction without negatively affecting the property of either the absolute and relative refractory periods or repetitive firing. On the other hand, 4-AP treatment resulted in an increase of both the relative and absolute refractory periods and the reduction of axonal capabilities to follow train stimuli. This phenomenon has been observed in both mechanically and chemically-injured axons (Jensen and Shi, 2003; Sun et al., 2010; Yan et al., 2016). Taken together, the results from this and other studies confirm that acrolein-mediated myelin damage, both in absence of (MS) or following CNS trauma (SCI), leads to potassium channel exposure and conduction block, which can then be reversed by potassium channel blockers, particularly 4-AP-3-MeOH.

    It is clear that functional deficits as a result of physically induced myelin damage can be reversed through the application of potassium channel blockers such as 4-AP and 4-AP-3-MeOH (Jensen and Shi, 2003; Sun et al., 2010; Shi and Sun, 2011; Yan et al., 2016). While 4-AP has previously been shown to be effective for improving axonal conduction caused solely by the chemical injury such as acrolein, a key factor in oxidative stress, we now know that 4-AP-3-MeOH has similar capabilities with perhaps even greater efficacy and fewer side effects (Shi and Sun, 2011; Yan et al., 2016). Consistent with the current study, 4-AP-3-MeOH has been shown to improve axonal conduction in EAE mice, the leading animal model of MS and is known to be associated with acrolein pathology (Leung et al., 2011). In summary, it appears that 4-AP-3-MeOH is effective in restoring axonal conduction as a result of both mechanical and chemical insults in animal models. The significance of these findings could potentially be translated into the effective use of 4-AP-3-MeOH for the treatment of axonal damage in both trauma and disease and serves as a viable alternative for 4-AP.

    Complete text is here:
    http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=8;spage=1226;epage=1227;aulast=Page

  5. Hi Zel, I still haven’t tried the 4-AP 3meoh, but I’m still considering it! I had the chance to try out Ampyra last month, and honestly I like the regular old 4-AP better. The Ampyra barely had an effect on my walking. Once
    I stopped Ampyra (took it for ten days), I went back on my 4-AP, and it worked better than ever! But, only for a week. I guess I build up a tolerance quickly, and I swear some capsules have more drug in them? Who knows. I see you were having trouble filling with Mod4All? I was on another site talking with someone who still uses the pharmacy. Hope you’re doing well!

    • Yes, I wish you can try 4-AP-3-MeOH as it’s definitely the best one.
      I am still trying to find stable supplier of clean 4-AP-3-MeOH compound.
      If you find such a compound-er pharmacy, please, let me know?!

  6. Pingback: My Future Therapy | MIRACLE OF WALK

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