While we are all trying to survive this pandemic turbulent year, many discoveries were made in search for the cure of damaged Spinal Cord.
Generally in search for SCI cure, focus is shifted from stem cells.
The most promising future therapies are based on custom, small molecule medications and genetic modifications of CNS nerve cells with task to make broken nerves to re-connect or even self-regenerate.
ReNetx is recruiting chronic SCI candidates for Human trial phase 2 of medication Axer-204 and all looks very promising so far.
NervGen is working on ISA NVG-291-R (Dr.J. Silver) and their stock. However, pipeline with human trial is not cleared yet.
Dr. Murray Blackmore Gene Therapy is very close to be unleashed from his lab to target and change non-restoring code within DNK of our CNS nerves.
Epac2 hydrogel from Aberdeen University is working marvels with rats broken spines.
Chondroitinase ABC , our old friend, has been stabilized for use in human body.
There are several notable mentions as:
Elezanumab, a drug for the treatment of acute SCI is in Fast track approval.
CPTX – new found compound to replace Cerebellin-1 protein that bridge bad connections in CNS nerves is marvelous drug that will fix all.
Alzheimer, SCI, Parkinson. Once when rats let it go from the lab.
CLP290 as KCC2 balance modulator to enable spared but not functioning nerves in SCI to transfer signal in incomplete spinal cord injury.
CLP290 is hopefully coming closer to human trials thanks to recent investment received by AXONIS
Simultaneous stimulation helped a spinal cord injury patient regain the ability to walk.
Once we have one or more researches with undeniable good results in human trials and approved as therapies to regenerate or somehow connect our broken nerves, this will still not make us to jump out from the wheelchair and start to walk again just like that.
Unfortunately, years of immobility made us very weak, soft, easy to break. In challenges and confrontation between our weak bodies and same, unforgiving, gravitational pull, many of Spinal Cord Injured patients would need months if not years of carefully customized physio-therapies to be able to grasp the most of independence and lost mobility in their lives.
For many of us weight support walking system will be necessity.
Functional Electrical neuro-muscular stimulation shows excellent results in jump-starting and reviving slow working and non working nerves.
This is exactly what is proposed in my New Walking Therapy that can be customized and used for any SCI patient that might be luckily in position to chase lost standing & walking ability.