2020 and SCI Cure Research

While we are all trying to survive this pandemic turbulent year, many discoveries were made in search for the cure of damaged Spinal Cord.
Generally in search for SCI cure, focus is shifted from stem cells.
The most promising future therapies are based on custom, small molecule medications and genetic modifications of CNS nerve cells with task to make broken nerves to re-connect or even self-regenerate.

ReNetx is recruiting chronic SCI candidates for Human trial phase 2 of medication Axer-204 and all looks very promising so far.
NervGen is working on ISA NVG-291-R (Dr.J. Silver) and their stock. However, pipeline with human trial is not cleared yet.
Dr. Murray Blackmore Gene Therapy is very close to be unleashed from his lab to target and change non-restoring code within DNK of our CNS nerves.
Epac2  hydrogel from Aberdeen University is working marvels with rats broken spines.
Chondroitinase ABC , our old friend, has been stabilized for use in human body.
***
There are several notable mentions as:
Elezanumab, a drug for the treatment of acute SCI is in Fast track approval.
CPTX – new found compound to replace Cerebellin-1 protein that bridge bad connections in CNS nerves is marvelous drug that will fix all.
Alzheimer, SCI, Parkinson. Once when rats let it go from the lab.
CLP290 as KCC2 balance modulator to enable spared but not functioning nerves in SCI to transfer signal in incomplete spinal cord injury.
CLP290 is hopefully coming closer to human trials thanks to recent investment received by AXONIS
Also,
Simultaneous stimulation helped a spinal cord injury patient regain the ability to walk.

Once we have one or more researches with undeniable good results in human trials and approved as therapies to regenerate or somehow connect our broken nerves, this will still not make us to jump out from the wheelchair and start to walk again just like that.
Unfortunately, years of immobility made us very weak, soft, easy to break. In challenges and confrontation between our weak bodies and same, unforgiving, gravitational pull, many of Spinal Cord Injured patients would need months if not years of carefully customized physio-therapies to be able to grasp the most of independence and lost mobility in their lives.
For many of us weight support walking system will be necessity.
Functional Electrical neuro-muscular stimulation shows excellent results in jump-starting and reviving slow working and non working nerves.
This is exactly what is proposed in my New Walking Therapy that can be customized and used for any SCI patient that might be luckily in position to chase lost standing & walking ability.


My Custom Walking Therapy

MW-card-2020
It is becoming more evident that incomplete Spinal Cord Injured patients can actually recover standing & walking  with continuous, persistent and programmed walking training thanks to neuro-plasticity and to re-igniting existing,  preserved but “slow” responding & sleeping nerves and weak muscles.

While I was attending attending assisted weight support walking therapy (no FES) – just at PACE exercise program with MacWheelers at McMaster University in Hamilton, I had a great improvement in my ability to push and step on the treadmill and my balance and metabolism had also improved tremendously.  However low exercise frequency with 2 training / walk per week (40 minutes per walk) and often interruptions just kept my body in so called Yo-Yo state with no chance to achieve any real progress.

I have envisioned my new custom walking therapy is with addition of walking FES – Functional Electric Stimulation and persistent Program with increased frequency & training length with at least 2 hours of walking practice per day with 4 to 5 times training per week, with for at least 5-8 months.

Addition of Functional Electrical neuro-muscular Stimulation (FES) to walking practices require licensed therapist and FES walking system.
Parastep
Now, Parastep system from Sigmedics.com.
Parastep  is only
commercially available walking FES system
I am aware of.

I have already used and tested Parastep shortly in private clinics in USA. and I have witnessed stepping improvement after just few sessions. comad-parastep

 

I am planning to use
Parastep for my walking
FES therapy.
Parastep is not available
for training anywhere
close to Toronto and possibly
need to be purchased.
Parastep  price is close
to CDN $ 20,000.

Some SCI Incomplete patients can stand and some can make few steps.
For them just Parastep and long, frequent walking training program should be sufficient.
Many others would need standing and over ground walking support.
Important note – For this therapy, overground weight support system should be used  – not treadmill weight support system as patient  need to self adjust walking / electrical stim rhythm.
I would also need to use overground weight support system as I have lost any standing ability 17 years after my injury.

According to my research LiteGait 330 4Home system or similar should be sufficient and up to this task. LiteGait 330 4Home
LiteGait 330 4Home can be purchased with shipping & taxes up to $ 10,000.

To get necessary equipment buy Parastep system and Weight support apparatus minimum CDN $ 30,000 for both devices need to be cashed out.

Also, to pay hours and hours of psychotherapies  through period of 5-8 months of intensive physio with this customized program, it is going to cost way more than equipment itself.

Total cost with equipment and 5-8 months of therapy can run from
$ 60,000 to $ 80,000 in my case.

My goal is to raise funds, buy equipment, organize and test this proposed therapy with equipment and in length & way proposed.

This New Envisioned Walking Therapy is customized for my situation according to my research and experience.
However this walking therapy slightly customized from patient to patient could help many with Incomplete Spinal Cord Injury and also to other patients with specific movement impairment.

One great upgrade can be added to my custom walking therapy if
Parastep FES walking system can be improved for quick application with programmable garment that would transfer functional electric stim.pants
Instead of placing individual electrodes on specific muscles every time when using Parastep, patient & therapist can use pants with electrodes already programmed for custom FES application and
just plug it in.
I am very excited this therapeutic combo might be available relatively soon.
After my research I have contacted  and connected people from Myant.ca and Sigmedics.com,
Realizing great opportunity of using this concept & therapeutic combo, both sides have decided to pursue this idea and enable this connection & create new therapeutic FES walking product.

Through year 2020 and pandemic slowing this research we hope to see restart of this project as soon as possible!
Some other exciting researches and results with promising human trials still happened in 2020 and Links to some of them are posted here.

Some references related to statements in this post can be found in my previous December 2019 post about New Walking therapy.

To make it possible, please
donate@miracleofwalk.com


3A933BfgJ5Vgzx7ndZminFT3zdnUd15Cam

New Walking Therapy

MW-card-2020
It is becoming more evident that incomplete Spinal Cord Injured patients can actually recover standing & walking  with continuous, persistent and programmed walking training thanks to neuro-plasticity and to re-igniting existing,  preserved but “slow” responding & sleeping nerves and weak muscles.

While I was attending attending assisted weight support walking therapy (no FES) – just at PACE exercise program with MacWheelers at McMaster University in Hamilton, I had a great improvement in my ability to push and step on the treadmill and my balance and metabolism had also improved tremendously.  However low exercise frequency with 2 training / walk per week (40 minutes per walk) and often interruptions just kept my body in so called Yo-Yo state with no chance to achieve any real progress.

I have envisioned my new custom walking therapy is with addition of walking FES – Functional Electric Stimulation and persistent Program with increased frequency & training length with at least 2 hours of walking practice per day with 4 to 5 times training per week, with for at least 5-8 months.

Addition of Functional Electrical neuro-muscular Stimulation (FES) to walking practices require licensed therapist and FES walking system.
Parastep
Now, Parastep system from Sigmedics.com.
Parastep  is only
commercially available walking FES system
I am aware of.

I have already used and tested Parastep shortly in private clinics in USA. and I have witnessed stepping improvement after just few sessions. comad-parastep

 

I am planning to use
Parastep for my walking
FES therapy.
Parastep is not available
for training anywhere
close to Toronto and possibly
need to be purchased.
Parastep  price is close
to CDN $ 20,000.

Some SCI Incomplete patients can stand and some can make few steps.
For them just Parastep and long, frequent walking training program should be sufficient.
Many others would need standing and over ground walking support.
Important note – For this therapy, overground weight support system should be used  – not treadmill weight support system as patient  need to self adjust walking / electrical stim rhythm.
I would also need to use overground weight support system as I have lost any standing ability 17 years after my injury.

According to my research LiteGait 330 4Home system or similar should be sufficient and up to this task. LiteGait 330 4Home
LiteGait 330 4Home can be purchased with shipping & taxes up to $ 10,000.

To get necessary equipment buy Parastep system and Weight support apparatus minimum CDN $ 30,000 for both devices need to be cashed out.

Also, to pay hours and hours of psychotherapies  through period of 5-8 months of intensive physio with this customized program, it is going to cost way more than equipment itself.

Total cost with equipment and 5-8 months of therapy can run from
$ 60,000 to $ 80,000 in my case.

My goal is to raise funds, buy equipment, organize and test this proposed therapy with equipment and in length & way proposed.

This New Envisioned Walking Therapy is customized for my situation according to my research and experience.
However this walking therapy slightly customized from patient to patient could help many with Incomplete Spinal Cord Injury and also to other patients with specific movement impairment.

One great upgrade can be added to my custom walking therapy if
Parastep FES walking system can be improved for quick application with programmable garment that would transfer functional electric stim.pants
Instead of placing individual electrodes on specific muscles every time when using Parastep, patient & therapist can use pants with electrodes already programmed for custom FES application and
just plug it in.
I am very excited this therapeutic combo might be available relatively soon.
After my research I have contacted  and connected people from Myant.ca and Sigmedics.com,
Realizing great opportunity of using this concept & therapeutic combo, both sides have decided to pursue this idea and enable this connection & create new therapeutic FES walking product.

Through year 2020 and pandemic slowing this research we hope to see restart of this project as soon as possible!

Some references related to statements in this post can be found in my previous December 2019 post about New Walking therapy.

Further Explanations of New Walking Therapy

People with Incomplete Spinal Cord Injury (SCI)  can restore walking but only if they actually try to walk again.
Locomat-Neurochangers-Toronto-Komad-Dec-11-2019
To begin this process, they need to use special support devices to enable proper walking technique in order to put their body through repetitive walking therapy rounds.

Majority of SCI individuals need “Gait training”, this is based on a body weight support machine. Treadmill and harness system are also part of this package.

There are several phases and modes of how walking can be done. This is based on the person’s capabilities to initiate stepping.

For many, robot walkers as Locomat
and THERA-Trainer lyra or REHA G-EO system are necessary for beginning of this process.

Assistive walking with weight support – Click to see short Videoassisted-walk-01

Some of us that can slightly initiate stepping but lacking intensity and control of movement and need Manual assistance of 2 “walkers” to move legs in rhythmic stepping pattern on treadmill. With this exercise stepping pattern is improving tremendously!

Another progressive step is the application of Functional neuro-muscular FES stimulation (with or without a weight support) walking training . This type of system is known as Parastep- which was invented around a quarter century ago, and is highly underrated as a therapy tool for Incomplete SCI patients.comad-parastep
The way how Parastep works is simple –  when patient try to move the right leg as at the same time press right button on the walker. Small wearable computer send tiny electric stim through 6 over skin attached electrodes on each leg in programmed sequence. This stimulation generate muscle contraction exactly in order to make stepping motion with right leg. At the same time, muscles on the left leg receive signal to straight up and hold body weight on that side.
System Parastep is available from Sigmedics. Parastep is in use by many clinics in the USA. It can be used with and without weight support system that is sold separately.
Parastep, Walking FES as Therapeutic device would be more effective and much faster in application if improved with programmable FES garment.

Maybe the most important conclusion is that no walking therapy for SCI patients can be effective if is not performed in certain (1)frequency, (2)duration and (3)continuance with at least  3-4 trainings per week for 4-6 months!
Walking therapy is the only way to strengthen weak or to awake unused neuro-circuits and build (again) pattern based neural behavior that would further support patient walking rehabilitation.
Body-Mind connection, as patient need to highly focus on stepping and pushing, is also crucial element for faster rebuilding of walking neural pattern.
On the other side, failing to perform certain number of repetitions will prevent body to rebuild that neurological pattern.
With above exercises, patients improve very slowly and lose it in no time if stop exercising. This is known as Yo-Yo therapy effect.
hal
Next level of walking exercises has more modalities and different devices that can support patient.

Some people that still need help with stepping might get assistance by robotic devices (Keeogo or Hal or any other full or partial Exoskeleton devices);

Walking therapy is so effective according to Special Hospital for Spinal Cord Injuries in Kunming in China. After decades of experience Specialists in Kunming Chine claim that their method : Continuous walking over ground with high walker and no body weight support in length:  6 hours per day, 6 days per week and 6 months based on “tight rope walking” method – apparently is helping many SCI patients to recover to independent living and walking.
Dr-Wise-Kunming-rope-walkDr. Wise explain this walking technique on above photo

All above statements, photos and videos from Assisted Gait walking and Parastep use are my own experience and can be repeated and proven.

MW-card-2020

Power of Rehab

Desert-Reflection   In recent Interview Dr. Wise Young is sharing some findings regarding cell transplant trials and Rehab Importance regardless of age and years after injury.

Some excerpts from Interview with |September 3rd, 2019 from New Mobility Magazine:

     Animal studies have shown for a long time that spontaneous regeneration occurs in the spinal cord and that transplanted cells can improve the regeneration, but the regenerated axons are very unlikely to make exactly the same connections. Training is necessary for the brain to learn to interpret sensory signals and how to use the new connections

     We’re not talking about miracles here. Recovery in spinal cord injury can be helped by certain therapies and requires a huge commitment on the part of the people with SCI and their families to do the locomotor exercise, which is the most intensive exercise they’ll ever have. To take somebody who’s 20 years after spinal cord injury and expect them to walk without intensive training, that’s expecting a miracle to happen.

     One aspect of the studies was really unexpected — age and time after injury did not seem to make a difference. People that were in their 50s and 20 years after injury recovered as much and as well as those who were in their 20s and two years after injury

Read the full Interview here:
Without rehab no recovery of functions is possible.

Body Language – Reversed with NoGo Trap

Renetx
UPDATE: AFTER 1 YEAR SINCE THIS POST BELOW DRUG AXER-204 FROM RENETX IS RIGHT NOW IN FIRST HUMAN TRIAL NAMED “RESET”;
SEE MORE HERE

Human body makes intentional blocks to damaged nerves in our Spinal Cord to heal and grow back together.
Dr. Strittmatter from Yale have figured out how to reverse that “block” as natural body response and make nerves grows back together.
Lets see … when you cut or damage nerve in any other part of your body, that nerve will grow back together again… right!? Few months and you are ok…

But… that’s not the case if you have cut or damage nerves in major transmission cable going down within our spine transferring body internet  from brain to our muscles.
Even small damage in that finger thick gooey cord block communication and we stays paralyzed!
Body is intentionally making some protein inhibitors (Nogo-A, MAG and OMgp) that prevent damaged nerves in spinal cord and brain to joint again.
Why ?
No one knows ….is that bad design….survival of species … who cares!!!!

Just for the record – humans are not unique with this trouble! All rats, tigers, monkeys, horses and elephants are sharing the same luck with us after spine injury. Only Zebra fishes and Salamanders “knows” how to recover back…..

Dr. Strittmatter after decades of research has figured out how to prevent those inhibitors, kind of LeBron smash block those natural NoGo nerve growth blockers – and .. VOILA !!!!!   Nerves start to grows back together and happy rats are running again….
Wait…. this story has better outcome than “another 5 years”…

HUMAN TRIALS for cervical CHRONICALLY injured Spinal Cord patient are going to test this therapy (Intrathecal applied) late this 2018 or beginning of 2019 !!

CAN YOU BELIEVE IT !!!???
They already got funding and all is in rolling process!

Good Luck to us!!!

see more here
https://www.renetx.com/

 

 

 

Fantastic progress – 2018 summer-y

Sudenly, this 2018 summer, we have flood of crazy good lab results and confirmed neural regeneration (injured spinal cord and brain) using different methods and approaches. There is scope of few last months here.

The most recent finding is from Dr. Blackmore Lab.
blackmore
His team figured out how to push cells in damaged spinal cord to regenreate on molecular level:   https://www.blackmorelab.com/

 

Also, Dr. Silvers peptides are coming closer to human trial after NerveGen Pharma secured financing for this research.
https://www.nervgenpharma.com/technology
nervegen

 

Personally I was very excited to see discovery of compound CLP290 which enable preserved but inactive neural pathways in damaged spinal cord to start to transfer signals from brain to the body, signals that can be than easily retrained with repetitive exercises supported with trans-cranial electrical stim in plasticity process of recovery & rehab.

 

Than we see 3D printed Implant for damaged / cut-off spinal cord
lhttps://medicalxpress.com/news/2018-08-3d-printed-device-spinal-cord-injuries.html
5b6c4cb9638f5

 

There is also San Diego team Spinal cord neural stem cells created from human pluripotent stem cells research.

stem1

All for natural – Australian team find out that some local bush contain extract which help with stem cells regeneration:

Also scientists from UCLA figured out how to use magnets stimulation to recover bladder functio for some spinal cord injured patients.

Growth Cocktail Helps Restore Spinal Connections in the Most Severe Injuries
https://www.scientificamerican.com/article/growth-cocktail-helps-restore-spinal-connections-in-the-most-severe-injuries/

UCLA Scientists figure out how to virus deliver & genetically return clock of scar tissue making it to sprout & regrow nerves net and rewire spinal cord again.
https://www.nih.gov/news-events/news-releases/study-provides-early-recipe-rewiring-spinal-cords

After all we are also waiting for Dr. Ahlfors fortunafix.com restore therapy which is in brewing process, Dr. Wise USA trial for stem cells in preparation and BioArctic, Scandinavian trial in progress, things never looks so promising for devastating condition of SCI.

 

We need another 5 years, I guess, to see mass application for any of above.
In the most cases bureaucratic regulations and monetization process are making things move slower than our broken bodies will be able to endure.
But again …in 5 years, or maybe sooner… lucky ones (hope to be…) will feel that miracle of walk again!
in the meantime…

mice-spinal-cord-2

 

LaPradera Rehab Clinic @ Havana, Cuba

I have spent 4 weeks in Havana, Cuba in March 2018 attending Intensive Physio Rehabilitation program. In LaPradera clinic 20 km west of Havana they have excellent
equipped Medical Resort center with highly trained & professional and friendly personal and my stay there was very successful.

First part of program is comprehensive medical exam. After this exam doctors will propose workout and rehabilitation program.
They have well equipped gym and cabinets for Occupational therapies,
Electro-stimulation, Hydro-therapies, Locomat and Massage cabinet.
Nurses on site are trained and highly professional.
Physio-therapists very knowledgeable and friendly!
Rooms are clean, accessible with modern hospital bed, TV and air-condition.
There are some drawbacks as well.
Food in their clean Restaurant is good, not well seasoned IMO, but repetitive.
Internet access is only on certain spots in resorts where you have to use purchased cards (1 hour = 1$);
20180222_122653
The worst thing with LaPradera is extremely
high price of their service.
4 weeks there cost me CDN $ 7,800 + Airfare ($ 600);
Therapy would be definitely more effective if I had a chance to work hard there 3-4 or even 5 months but no budget for this venture.

I can still say my visit was successful! I met some very nice people, made friends with some and save myself for month from cold Canadian winter.If anyone need more details, please contact me with an email.
p.s.
Tip hard working Cuban people whenever you can and you will get better service. Don’t miss to see Tropicana Cabaret show while you in Havana.

Fortuna Fix

Scientists figure out how to re-program  patient skin stem cells into neural stem cells…
Fortuna Fix is working on two regenerative medicine solutions :
Proprietary technology platform drNPC based on direct reprogramming of somatic cells to neural precursor cells.
Regeneration Matrix (RMx) based on a proprietary technology platform for the production of regenerative implants.
http://fortunafix.com
fortunafix