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Renetx
Human body makes intentional blocks to damaged nerves in our Spinal Cord to heal and grow back together.
Dr. Strittmatter from Yale have figured out how to reverse that “block” as natural body response and make nerves grows back together.
Lets see … when you cut or damage nerve in any other part of your body, that nerve will grow back together again… right!? Few months and you are ok…

But… that’s not the case if you have cut or damage nerves in major transmission cable going down within our spine transferring body internet  from brain to our muscles.
Even small damage in that finger thick gooey cord block communication and we stays paralyzed!
Body is intentionally making some protein inhibitors (Nogo-A, MAG and OMgp) that prevent damaged nerves in spinal cord and brain to joint again.
Why ?
No one knows ….is that bad design….survival of species … who cares!!!!

Just for the record – humans are not unique with this trouble! All rats, tigers, monkeys, horses and elephants are sharing the same luck with us after spine injury. Only Zebra fishes and Salamanders “knows” how to recover back…..

Dr. Strittmatter after decades of research has figured out how to prevent those inhibitors, kind of LeBron smash block those natural NoGo nerve growth blockers – and .. VOILA !!!!!   Nerves start to grows back together and happy rats are running again….
Wait…. this story has better outcome than “another 5 years”…

HUMAN TRIALS for cervical CHRONICALLY injured Spinal Cord patient are going to test this therapy (Intrathecal applied) late this 2018 or beginning of 2019 !!

CAN YOU BELIEVE IT !!!???
They already got funding and all is in rolling process!

Good Luck to us!!!

see more here
https://www.renetx.com/

 

 

 

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Sudenly, this 2018 summer, we have flood of crazy good lab results and confirmed neural regeneration (injured spinal cord and brain) using different methods and approaches. There is scope of few last months here.

The most recent finding is from Dr. Blackmore Lab.
blackmore
His team figured out how to push cells in damaged spinal cord to regenreate on molecular level:   https://www.blackmorelab.com/

 

Also, Dr. Silvers peptides are coming closer to human trial after NerveGen Pharma secured financing for this research.
https://www.nervgenpharma.com/technology
nervegen

 

Personally I was very excited to see discovery of compound CLP290 which enable preserved but inactive neural pathways in damaged spinal cord to start to transfer signals from brain to the body, signals that can be than easily retrained with repetitive exercises supported with trans-cranial electrical stim in plasticity process of recovery & rehab.

 

Than we see 3D printed Implant for damaged / cut-off spinal cord
lhttps://medicalxpress.com/news/2018-08-3d-printed-device-spinal-cord-injuries.html
5b6c4cb9638f5

 

There is also San Diego team Spinal cord neural stem cells created from human pluripotent stem cells research.

stem1

All for natural – Australian team find out that some local bush contain extract which help with stem cells regeneration:

Also scientists from UCLA figured out how to use magnets stimulation to recover bladder functio for some spinal cord injured patients.

Growth Cocktail Helps Restore Spinal Connections in the Most Severe Injuries
https://www.scientificamerican.com/article/growth-cocktail-helps-restore-spinal-connections-in-the-most-severe-injuries/

UCLA Scientists figure out how to virus deliver & genetically return clock of scar tissue making it to sprout & regrow nerves net and rewire spinal cord again.
https://www.nih.gov/news-events/news-releases/study-provides-early-recipe-rewiring-spinal-cords

After all we are also waiting for Dr. Ahlfors fortunafix.com restore therapy which is in brewing process, Dr. Wise USA trial for stem cells in preparation and BioArctic, Scandinavian trial in progress, things never looks so promising for devastating condition of SCI.

 

We need another 5 years, I guess, to see mass application for any of above.
In the most cases bureaucratic regulations and monetization process are making things move slower than our broken bodies will be able to endure.
But again …in 5 years, or maybe sooner… lucky ones (hope to be…) will feel that miracle of walk again!
in the meantime…

mice-spinal-cord-2

 

I have spent 4 weeks in Havana, Cuba in March 2018 attending Intensive Physio Rehabilitation program. In LaPradera clinic 20 km west of Havana they have excellent
equipped Medical Resort center with highly trained & professional and friendly personal and my stay there was very successful.

First part of program is comprehensive medical exam. After this exam doctors will propose workout and rehabilitation program.
They have well equipped gym and cabinets for Occupational therapies,
Electro-stimulation, Hydro-therapies, Locomat and Massage cabinet.
Nurses on site are trained and highly professional.
Physio-therapists very knowledgeable and friendly!
Rooms are clean, accessible with modern hospital bed, TV and air-condition.
There are some drawbacks as well.
Food in their clean Restaurant is good, not well seasoned IMO, but repetitive.
Internet access is only on certain spots in resorts where you have to use purchased cards (1 hour = 1$);
20180222_122653
The worst thing with LaPradera is extremely
high price of their service.
4 weeks there cost me CDN $ 7,800 + Airfare ($ 600);
Therapy would be definitely more effective if I had a chance to work hard there 3-4 or even 5 months but no budget for this venture.

I can still say my visit was successful! I met some very nice people, made friends with some and save myself for month from cold Canadian winter.If anyone need more details, please contact me with an email.
p.s.
Tip hard working Cuban people whenever you can and you will get better service. Don’t miss to see Tropicana Cabaret show while you in Havana.

Scientists figure out how to re-program  patient skin stem cells into neural stem cells…
Fortuna Fix is working on two regenerative medicine solutions :
Proprietary technology platform drNPC based on direct reprogramming of somatic cells to neural precursor cells.
Regeneration Matrix (RMx) based on a proprietary technology platform for the production of regenerative implants.
http://fortunafix.com
fortunafix

NoGo Trap

            CHEMICAL WAR AGAINST SCI or New pharma approach to repair broken SCI are on the horizon

How about chasing   ACROLEIN SCAVENGER, Aiming 14-3-3 – Target and setting up NoGo Trap.  Sounds like some new space war strategy. And they are actually part of the same troops intending to attack our mutual enemy.

After the story about Acrolein Scavenger in form of drug Dimercaprol  and story about Fungus produced molecule Fusicoccin-A 14-3-3  in the beginning of this year, we can read these days about another pharmacology approach that might help people with Spinal Cord Injury.

There is now NoGo Trap – pharmacology procedure that will allow broken nerves in damaged Spinal Cord to grow back together.

NoGo Trap – neuro-restorative Nogo Receptor platform technology discovered by Stephen Strittmatter, M.D., Ph.D., at Yale University and founder and scientific advisor to ReNetX. Human trial should be ready by the end of 2018. Read more here. or hereneurons-33

 

 

Pilates adjusted for SCI

zebrafish
View full article »

My Future Therapy

Update October 2017

ABSTRACT: My plan is to dedicate six months of heavy workout that includes of 3-4 hours daily weight support walking physio-therapy based on programmed
neuro-muscular stim (Sigma Parastep);
To fortify my walking therapy, I will also use novel medicine:
4AP-3-MeOH – potassium channel blocker to enhance my neuro-signals.

You can support me here

 

Here is longer explanation below with more options.

Below I have posted “My Future therapy” article in April 2017, but this should be renamed as “My Science Fiction future therapy”.
Realistically, chances for me to put together some new elements and create proposed new therapy, without serious funding and connections, are bleak.
Seriously. .. I wish I can have a chance to test this as proposed Unique Therapy, but…
For now I am trying to create home program, to use equipment and resources that I already have, and to keep myself in decent form.
Next, more realistic step will be to figure out if I can access some rehab with established PARASTEP microcomputer controlled functional neuromuscular stimulation (FNS) system walking therapy with Gait support.
I have already tested briefly this therapy in Sci-Step, Mason Ohio (now closed) clinic and seems to be working fantastic for me. Now – I am in search for affordable clinic…
If is good…
If lottery hits me or some willing-to-invest-in-crazy-idea investor open wallet, I can purchase equipment PARASTEP and NxStep Biodex gait system and put together with space & therapist for 6-9 months run for approx. CDN $ 70-80,000.

 

My Future Self-Invented Therapy will be combined of:

1. Extensive Gait walking [1]

2.  4-AP-3-MeOH (new experimental medication)

3. Virtual Reality Program (adjusted for Incomplete SCI)

Let me explain in few words what I have learned after 14 years in wheelchair and after so many Yo-Yo physical rehab attempts, self-testing experimental medication and research. I have figured out that only way to make difference and preserve achieved progress is to stop waiting and go radical & invent my own therapy. [2]

PROGRESS IS POSSIBLE

Victims of Spinal cord injuries can recover to certain extent with a long and custom tailored physiotherapy.

Unfortunately, this fact is not everywhere accepted or is not welcomed with healthcare systems as too long = too expensive approach.

Patient’s are rather sold all kinds of wheelchairs & assistive equipment, told lies of possible outcome as “you’d never walk again” or wishes as “medicine science will come up with cure in 5 years”.

It’s easier, less expensive & stressful to teach such a patient to accept life in wheelchair than proceed with 3-4-5 hours 1:1 physio therapies daily with “uncertain outcome”. This approach looks better on statistic charts too for any rehab or hospital. However, this is not the best choice for injured, paralyzed patients, unfortunately. [3]

IN-COMPLETE

In more than 80% cases, spinal cord injuries are caused with contusion or bruise on one part of spinal cord where larger portion of spinal cord is preserved. Such a patients with Incomplete SCI have more chance to recover – due to neuroplasticity [4] – than victims with totally cut off cord .

It is proven that healthy part of brain or spinal cord can take over function from damaged part. But, unfortunately, this will not going to happen by itself. Only way neuroplasticity recovery happens is after countless move or try to move repetitions. This process is painfully slow and as soon as certain exercise procedure / pattern is stopped, patient loosing whatever progress was made exponentially fast.

Luckily, there are some new tricks in bag that can help this process shorten with more chance for recovery.

GAIT AND ROBOTIC WALK

First, there are different equipment for suspended weight / gait walk training and robotic suites with sensory to detect patient ability to move and to assist motion  close to real standing and walking pattern.

VIRTUAL REALITY TRICK

There are also recent findings that “tricking” brain with Virtual reality

can accelerate brain and spinal cord neuroplasticity process.

Group of scientist’s from Brazil combined repetitive walking technique with virtual reality & brain interface achieve incredible results with Complete spinal cord injured patients[5].

Also, more and more researches and companies working toward a goal to accommodate Virtual Reality program for certain rehab procedures[6].

EXPERIMENTAL MEDICATION – 4-AP-3-MeOH

Chances are that Incomplete injuries will recover faster, with similar program.

Incomplete injuries must not have Brain interface (cap with electrodes) at all.

To help existing partially damaged or impaired nerves better conduct signals from the brain, potassium channel blockers are used for decades.

The latest, 4-AP-3-MeOH blocker, experimental medication makes big difference in exercise outcome with less side effects than 4-AP or (F)Ampyra [7].

To summarize above, I am planning to test this combined therapy ASAP!!

Gait walking + 4-AP-3-MeOH + Virtual Reality Program 

If I prove this with me going back on my feet again after 14 years in wheelchair,

I can help to change life to many Incomplete Spinal Cord Injured patients as they

will have all details of this program / therapy available for FREE !

Right now, I am in search to secure stable supply of experimental medication 4-AP-3-MeOH.

Second thing – I will try to obtain VR program that will help me in this process.

I am also working hard to be able to allocate funds for this self-help experiment / therapy.

Z.K.

[1] I am C-6 Incomplete SCI and my legs can not hold me. I need gait -suspension weight support to be able to try to make steps. In several years, as a member of University of McMaster special gym for Spinal Cord Injury rehab I was walking above treadmill with suspended weight and stepping help by couple of student volunteers and my steps had improved considerably, even I was walking only twice per week by 40 minutes. However, I stay without funding once when they increased price 10 times in September 2016 and I have stop with walking therapy. In some previous rehab attempts and according to  some other

walking therapy achievements [a] I know that at least 6 months programmed walking therapy with at least 20 hours walking per week with  4-AP-3-MeOH potassium channel blocker and Virtual reality program help will help me to walk again!!

[2]  Yo-Yo rehab effect is known to patients and physio-therapists and could be overcome only with some new, radical approach.

[3] From my personal experience with Canadian Health Care system;

[4] The human brain and spinal cord has the amazing ability to reorganize itself by forming new connections between neurons – this is called NeuroPlasticity.

[5] See https://www.nature.com/articles/srep30383

[6] MindMaze, company with successful VR program for rehab of stroke victims is moving closer, according to them, toward VR rehab program for Spinal cord injuries. Also some other sources of Virtual Reality in rehab found here: [a] [b] [c]

[7] Unfortunately, this new medication is tested on animals only and group of self-testing volunteers (including me) and it’s not always easy to obtain. [4a] [4b] [4c] [4d] [4e]

This is the Digest of newest discoveries and movement in Spinal Cord Injury Therapy and Recovery field.
green-light-walk

Man with SCI (complete para) walks with no robotic suite – only with brain / leg interface. also thanks to Bluetooth…
https://www.engadget.com/2015/09/24/paraplegic-walks-with-mind-control/

University of Edmonton team figure out huge OXYGEN role in recovery
http://edmontonjournal.com/news/local-news/university-of-alberta-discovery-offers-promise-of-new-therapies-for-spinal-cord-injuries and also this link

Dr. Shi and his team discover that old drug Dimercaprol can disolve poison Acrolein formed in our nerves after SCI. Only on animals for now…
https://www.purdue.edu/newsroom/releases/2017/Q1/an-old-drug-with-new-potential-wwii-chemical-weapon-antidote-shows-early-promise-as-treatment-for-spinal-cord-injuries.html   

red-maple-leaf
Go Canada Go!!! Canadian team with Jan-Eric Ahlfors with his autologus stem cell project and Krembil Neuroscience Center with Dr. Fehlings and other masters of Neuroscience
coming up together with Fortuna Fix promise to move things faster toward SCI CURE!

My Future Therapy

Update October 2017

ABSTRACT: My plan is to dedicate six months of heavy workout that includes of 3-4 hours daily weight support walking physio-therapy based on programmed
neuro-muscular stim (Sigma Parastep);
To fortify my walking therapy, I will also use novel medicine:
4AP-3-MeOH – potassium channel blocker to enhance my neuro-signals.

Below I have posted “My Future therapy” article in April 2017, but this should be renamed as “My Science Fiction future therapy”.
Realistically, chances for me to put together some new elements and create proposed new therapy, without serious funding and connections, are bleak.
Seriously. .. I wish I can have a chance to test this as proposed Unique Therapy, but…
For now I am trying to create home program, to use equipment and resources that I already have, and to keep myself in decent form.
Next, more realistic step will be to figure out if I can access some rehab with established PARASTEP microcomputer controlled functional neuromuscular stimulation (FNS) system walking therapy with Gait support.
I have already tested briefly this therapy in Sci-Step, Mason Ohio (now closed) clinic and seems to be working fantastic for me. Now – I am in search for affordable clinic…
If is good…
If lottery hits me or some willing-to-invest-in-crazy-idea investor open wallet, I can purchase equipment PARASTEP and NxStep Biodex gait system and put together with space & therapist for 6-9 months run for approx. CDN $ 70-80,000.
I wish…

——————————————————————————-
Original post from April 2017

My Future Therapy (or My Science Fiction future therapy) should be combined of:

1. Extensive Gait walking [1]
2.  4-AP-3-MeOH (new experimental medication)
3. Virtual Reality Program (adjusted for Incomplete SCI)

Let me explain in few words what I have learned after 14 years in wheelchair and after so many Yo-Yo physical rehab attempts, self-testing experimental medication and research. I have figured out that only way to make difference and preserve achieved progress is to stop waiting and go radical & invent my own therapy. [2]

PROGRESS IS POSSIBLE

Victims of Spinal cord injuries can recover to certain extent with a long and custom tailored physiotherapy.
Unfortunately, this fact is not everywhere accepted or is not welcomed with healthcare systems as too long = too expensive approach.
Patient’s are rather sold all kinds of wheelchairs & assistive equipment, told lies of possible outcome as “you’d never walk again” or wishes as “medicine science will come up with cure in 5 years”.
It’s easier, less expensive & stressful to teach such a patient to accept life in wheelchair than proceed with 3-4-5 hours 1:1 physio therapies daily with “uncertain outcome”. This approach looks better on statistic charts too for any rehab or hospital. However, this is not the best choice for injured, paralyzed patients, unfortunately. [3]

IN-COMPLETE

In more than 80% cases, spinal cord injuries are caused with contusion or bruise on one part of spinal cord where larger portion of spinal cord is preserved. Such a patients with Incomplete SCI have more chance to recover – due to neuroplasticity [4] – than victims with totally cut off cord .
It is proven that healthy part of brain or spinal cord can take over function from damaged part. But, unfortunately, this will not going to happen by itself. Only way neuroplasticity recovery happens is after countless move or try to move repetitions. This process is painfully slow and as soon as certain exercise procedure / pattern is stopped, patient loosing whatever progress was made exponentially fast.

Luckily, there are some new tricks in bag that can help this process shorten with more chance for recovery.

GAIT AND ROBOTIC WALK

First, there are different equipment for suspended weight / gait walk training and robotic suites with sensory to detect patient ability to move and to assist motion  close to real standing and walking pattern.

VIRTUAL REALITY TRICK

There are also recent findings that “tricking” brain with Virtual reality
can accelerate brain and spinal cord neuroplasticity process.
Group of scientist’s from Brazil combined repetitive walking technique with virtual reality & brain interface achieve incredible results with Complete spinal cord injured patients[5].
Also, more and more researches and companies working toward a goal to accommodate Virtual Reality program for certain rehab procedures[6].

EXPERIMENTAL MEDICATION – 4-AP-3-MeOH

Chances are that Incomplete injuries will recover faster, with similar program.
Incomplete injuries must not have Brain interface (cap with electrodes) at all.
To help existing partially damaged or impaired nerves better conduct signals from the brain, potassium channel blockers are used for decades.
The latest, 4-AP-3-MeOH blocker, experimental medication makes big difference in exercise outcome with less side effects than 4-AP or (F)Ampyra [7].

To summarize above, I am planning to test this combined therapy ASAP!!
Gait walking + 4-AP-3-MeOH + Virtual Reality Program 
If I prove this with me going back on my feet again after 14 years in wheelchair,
I can help to change life to many Incomplete Spinal Cord Injured patients as they
will have all details of this program / therapy available for FREE !

Right now, I am in search to secure stable supply of experimental medication 4-AP-3-MeOH.
Second thing – I will try to obtain VR program that will help me in this process.
I am also working hard to be able to allocate funds for this self-help experiment / therapy.

Z.K.

[1] I am C-6 Incomplete SCI and my legs can not hold me. I need gait -suspension weight support to be able to try to make steps. In several years, as a member of University of McMaster special gym for Spinal Cord Injury rehab I was walking above treadmill with suspended weight and stepping help by couple of student volunteers and my steps had improved considerably, even I was walking only twice per week by 40 minutes. However, I stay without funding once when they increased price 10 times in September 2016 and I have stop with walking therapy. In some previous rehab attempts and according to  some other
walking therapy achievements [a] I know that at least 6 months programmed walking therapy with at least 20 hours walking per week with  4-AP-3-MeOH potassium channel blocker and Virtual reality program help will help me to walk again!! 

[2]  Yo-Yo rehab effect is known to patients and physio-therapists and could be overcome only with some new, radical approach.

[3] From my personal experience with Canadian Health Care system;

[4] The human brain and spinal cord has the amazing ability to reorganize itself by forming new connections between neurons – this is called NeuroPlasticity.

[5] See https://www.nature.com/articles/srep30383

[6] MindMaze, company with successful VR program for rehab of stroke victims is moving closer, according to them, toward VR rehab program for Spinal cord injuries. Also some other sources of Virtual Reality in rehab found here: [a] [b] [c]

[7] Unfortunately, this new medication is tested on animals only and group of self-testing volunteers (including me) and it’s not always easy to obtain. [4a] [4b] [4c] [4d] [4e]